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L'Agenzia Europea dei Medicinali a seguito di nuove segnalazioni di epatotossicità grave associate all'uso di Valdoxan e Thymanax. Successful Use of Agomelatine in The Treatment of Major. Depression. Agomelatine reversal of escitalopram-induced apathy: a case report. In Italia la molecola è venduta dalla società farmaceutica Servier, che la ha anche sviluppata, con il nome commerciale di Valdoxan e Thymanax. amlodipine verapamil combination Agomelatine, a new pharma Agomelatine, a unique receptor profile: TCA fluoxetine paroxetine escitalopram mirtazapine Agomelatine. Escitalopram – SSRI. ✓ Agomelatine – MT agonist 5HT2C antagonist. ✓ Selegiline patch – transdermal. MAOI. ✓ Gepirone – 5HT1A agonist. ✓ NK-1. Aim of this work was to analyse possible effects of chronic agomelatine on time-dependent changes of different intracellular signalling. 013 Effects of agomelatine compared to escitalopram on motivation in healthy male and female volunteers after 9 weeks of treatment. 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