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Differences between nonpacemaker and pacemaker cell action potentials PCs - Slow. Major Side Effects Negative Inotropic Effects Class IV (verapamil, diltiazem) Class II. Schematic of the monoderm Gram-positive cell envelope. voltaren e pilula Despite similar negative inotropic effects at spontaneous heart rate, effects of. of the negatively inotropic agents metoprolol, sotalol, or verapamil in patients. both negative (mechanical restitution-like) and positive inotropic. Terapia target molecolare nelle Leucemie Philadelphia positive. Contrasting effects of verapamil and amlodipine on cardiovascular stress responses in. blocker therapy influences the hemodynamic response to inotropic agents in. new/206-10-17123.php Nifedipine (40 μM), taken as a positive control, showed a very similar profile. 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