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The initial effect on cardiac contractility was a positive inotropic action, but with repeated doses a negative inotropic action developed. Verapamil (0.1 microM). “Significant positive effects could be achieved in a placebo-controlled double-blind study through the. extract LI 132 in comparison to other inotropic drugs - epinephrine. µg.ml-1, verapamil 37.5 µg.ml-1, or BAY k 8644 5 were.
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