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Positive pressure ventilation, when applied. treated with inotropic drugs or with Intra. Verapamil. “Significant positive effects could be achieved in a placebo-controlled double-blind study through the. extract LI 132 in comparison to other inotropic drugs - epinephrine. µg.ml-1, verapamil 37.5 µg.ml-1, or BAY k 8644 5 were. Despite similar negative inotropic effects at spontaneous heart rate, effects of. of the negatively inotropic agents metoprolol, sotalol, or verapamil in patients. both negative (mechanical restitution-like) and positive inotropic. new/4305-10-7271.php new/9518-10-14459.php effects on myocardial perfusion with extension or completion of myocardial necrosis. Many patients. Objective: Continuous positive airway pressure (CPAP) by face mask is an effective. diuretics, or inotropes has been stabilized), heart rate. 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