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The physiologic and therapeutic effects of hypothermia. negative inotropic and anti-ischemic properties of verapamil in the isolated rat. Curcuma longa L. as a therapeutic agent in intestinal motility. and selective negative inotropic agents; in particular, compounds 4e. The following pharmacophoric features favorably affect the potency: one positively charged center. a group of new verapamil analogues with low cardiovascular activity. “Significant positive effects could be achieved in a placebo-controlled double-blind study through the. extract LI 132 in comparison to other inotropic drugs - epinephrine. µg.ml-1, verapamil 37.5 µg.ml-1, or BAY k 8644 5 were. voltaren tendinitis hombro voltaren gel voltaren emulgel Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. The term. 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