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Physiological serum levels of calcitriol can suppress nonrenal calcitriol synthesis. almost 50% of the administered vitamin D is rapidly converted to 25(OH)D at. 4) A DNA variant in the angiotensin-converting enzyme gene locus. 92) The effect of vitamin D3 on CD 34 progenitor cells in vitamin D deficiency rickets. in ranl failure: role of phosphorus and its effects on calcitriol. Calcitriol, 1,25-dihydroxyvitamin D, is converted in the kidneys from calcidiol. 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