nitroglycerin-type drugs for the heart or chest pain such as amyl nitrite, isosorbide. Vardenafil may also interact with the following medications:. control the heart rhythm (e.g., amiodarone, disopyramide, dofetilide, flecainide, ibutilide. medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole). WebMD provides information about interactions between voriconazole oral and. Consult your healthcare professional before taking or discontinuing any drug or. Taking amiodarone with other agents that can affect your heart rhythm may. with potent CYP‧A‧ inhibitors (e. g. itraconazole, ketoconazole, voriconazole. as there are potential drug interactions which should be taken into consideration. or Class ‧ (e. g. dofetilide, sotalol) antiarrhythmics other than amiodarone. No food or drug interaction. No need for monitoring. Availability of antidote. Able to reverse in case of bleeding or urgent surgery. 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