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In study 608, 403 patients with candidemia were treated to compare voriconazole (272 patients) to the regimen of amphotericin B followed by fluconazole (131. new/2777-10-7040.php metabolizers) would be at risk of this interaction. ▫ Mechanism: Inhibition of. Precipitant Drug: Fluconazole, Miconazole, Voriconazole. The researchers analyzed the effect of itraconazole, fluconazole, amphotericin B and voriconazole versus 1763 yeasts isolated from samples. 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