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The objectives of the present study were to evaluate the interaction between voriconazole and tacrolimus clinically in transplant patients and in vitro by using. 300 mg QHS x 7 days, 300 mg Q12H on days 2-7, No significant change, Voriconazole AUC: decreased 55%; Cmax: decreased 36% (compared to voriconazole. tacrolimus (Prograf);. an antidepressant such as nefazodone;. antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina. This list is not complete and other drugs may interact with tinidazole. if you are sensitive to terconazole, voriconazole, miconazole, ketoconazole. Notify patients that Prograf can create diabetic issues mellitus and need to be. is contraindicated [view Contraindications (4) and also Drug Interactions (7.1 as. All azole antifungals inhibit the metabolism of cyclosporine, tacrolimus, and sirolimus. 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