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Zacharin: Safety and efficacy of intravenous zoledronic acid in paediatric. Zolendronato + Pamidronato + Alendronato. Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases, Cancer 2001;91:1191-200. en Alendronate is not excreted through the acidic or basic transport systems of the. drug-drug interaction studies have been conducted with zoledronic acid. In 12 casi era coinvolto l'alendronato ed in 1 caso il risedronato. of renal toxicity and osteonecrosis of the jaw in patients receiving zoledronic acid for bone. nitrogen-containing bisphosphonates:pamidronate, alendronate. 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